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The twenty-first century will continue to produce major
advances in medicines and medicine delivery.Nature, however,
is also a resilient foe.Diseases and organisms develop resistance
to existing drugs so that new molecules must be constantly
sought. This is particularly true for anti-infective and anticancer
agents. Additionally, new and more lethal forms of
existing diseases can rapidly develop and with the ease of travel
can easily assume pandemic form. Hence the current concerns
about avian flu. Also, diseases that have been previously dormant
or geographically circumscribed may suddenly break out
worldwide. In this way, for instance, an Ebola epidemic would
produce many casualties. Finally, there are serious concerns for
man-made epidemics through the deliberate spread of existing
biological disease agents or through the introduction of a laboratory-
manufactured or rejuvenated organism such as smallpox.
It is therefore imperative that the search for new
medicines continues.
All of us at some point in life will take a medicine, even if
it is only aspirin for a headache. For some individuals, drug use
will be constant throughout life, as in the current treatment of
AIDS, or will take place only during a certain stage, such as a
woman taking hormonal contraceptives during her period of
fertility. Quite generally, as we age we will likely be exposed to
a variety of medications from childhood vaccines to painrelieving
drugs in a terminal disease. It is not easy to get accurate
and understandable knowledge about the drugs that are
used to treat diseases. There are, of course, highly specialized
volumes and periodicals for the physician and scientist, but
these demand a substantial knowledge basis and experience to
be fully understood. Advertising on television provides only
fleeting information and is usually directed at a single drug;
hence the viewer has no means to make a critical or knowledgeable
evaluation. The intent of this series of books—Drugs:
The Straight Facts—is to present to students a readable, intelligent,
and accurate description of drugs available for specific
diseases, why and how they are used, their limitations, and
their side effects. It is our hope that this will provide students
with sufficient information to satisfy their immediate needs
and give them the background to ask intelligent questions of
their health care providers when the need arises.
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